WP4. Models of osteoreparation

Leader: Prof. dr Stevo Najman

The subproject Models of osteoreparation deals with the design and methods of producing bone implants from biomaterials, enriched with ostegenic molecules and populated with osteogenic cells, which would be based on imitation of microstructures and functions of natural bone. In order to solve the lack of bone mass of different etiology, implantation of biomaterials like bone substitutes as an alternative to the autografting and alografting is increasingly used today. Good bone substitute is a support for the cell attachment, proliferation, differentiation and migration, allowing the formation and growth of bone tissue, revascularization, osteointegration, the gradual replacement of newly formed bone. Applied biomaterial has to have adequate chemical and physical structure, micro and macroporosity, mechanical and biological properties. Preparation of biomaterials as bone tissue matrix that is populated by ostegenic cells is the latest approach in osteoregenerative therapy. This subproject will design and model the bone tissue scaffold, by applying the principles of CATE (Computer-aided tissue engineering), so that scaffolds reflect the local structure of the injured bone as close as possible.