Project coordinator: Prof. dr Miroslav Trajanovic

The work on the project includes research and management activities. Research activities are conducted under the following sub-projects: Definition of requirements, validation and application of the model, Geometric models, Prediction-simulation models, Models of osteoreparation, Support to exploitation of the results. Each model is developed for solving of a specific problem in preclinical and clinical practice.

WP1. Definition of requirements, validation and application of the model

Leader: Prof. dr Milorad Mitkovic

The goal of the sub-project Definition of requirements, validation and application of the model is to define the required models in terms of their purpose, features, validation and application methods. Validation of solutions obtained by applying the model will be done in clinical conditions. Specific goal of this sub-project is to create conditions for application of the solution. This includes the dissemination of scientific and technical information on the solution and definition of procedures and guidelines for application.

WP2. Geometric models

Leader: Prof. dr Miodrag Manic

Sub-project Geometric models aims at developing generic parametric 3D models of most relevant bones. Parametric model of the bone includes the outer surfaces and inner volumes, defined by mathematical and logical relations. In these relations, a number of variables will be set as the model arguments, which in the terminology of CAD (Computer Aided Design) systems are called (geometric) parameters. By changing some parameters of a generic 3D model it is possible to obtain a geometric model of specific patients bone. The data which are necessary for the creation of generic 3D models of individual bones are obtained from CT scans of bone-joint system. Developed 3D models of bones are the basis for creating other models. The second part of this sub-project refers to the use of bone models for: Design of custom metal implants and fixators and design of technology of their production; Determination of the morphology and size of the missing pieces of bone; Production of non-metallic non-biodegradable implants using rapid prototyping (RP) technologies; Production of biodegradable implants using RP technologies.

WP3. Prediction-simulation models

Leader: dr Nikola Korunovic

The third sub-project deals with prediction and simulation models. It is known that after the installation of breast implants and fixators, statics and dynamics of bone-joint system changes. These changes may lead to ruptures of bones or bone implants. Hence, this sub-project aims at developing models for prediction and optimization of mechanical behavior of assemblies that consist of human bones and osteo-fixation material (OM) under realistic load conditions, using finite element method. For the prediction of fracture risk for patients with osteoporosis, bone tissue 3D model will be used, developed by 3D reconstruction from serial pathohistological slices of bones, which are obtained by biopsy and necropsy. The thickness of cortical bone, the appearance of defects in bone plates and disappearance of bone sticks will be estimated, as well as topology and orientation, for patients of different ages and sexes. Planning and practicing surgery is one of the most important steps in the application of methods of surgical treatment of bone-joint system. Hence, within the sub-project, software tools for planning and simulation of surgical and orthopedic intervention in 3D space will be developed.

WP4. Models of osteoreparation

Leader: Prof. dr Stevo Najman

The subproject Models of osteoreparation deals with the design and methods of producing bone implants from biomaterials, enriched with ostegenic molecules and populated with osteogenic cells, which would be based on imitation of microstructures and functions of natural bone. In order to solve the lack of bone mass of different etiology, implantation of biomaterials like bone substitutes as an alternative to the autografting and alografting is increasingly used today. Good bone substitute is a support for the cell attachment, proliferation, differentiation and migration, allowing the formation and growth of bone tissue, revascularization, osteointegration, the gradual replacement of newly formed bone. Applied biomaterial has to have adequate chemical and physical structure, micro and macroporosity, mechanical and biological properties. Preparation of biomaterials as bone tissue matrix that is populated by ostegenic cells is the latest approach in osteoregenerative therapy. This subproject will design and model the bone tissue scaffold, by applying the principles of CATE (Computer-aided tissue engineering), so that scaffolds reflect the local structure of the injured bone as close as possible.

WP5. Support to exploitation of the results

Leader: Asst. Prof. dr Dragan Misic

The main objective of sub-project Support to the exploitation of the results is to develop methods and tools that support the development of business-research environment for the implementation of relevant products and services. The subject of these methods and tools are the transfer of knowledge on the developed models, technology planning, decision support in configuration of individual companies and supply chains and ensuring the high quality. Those methods and tools should support the rapid creation of business-research environment, using the potentials of flexible small and medium enterprises. New methods and tools are characterized by built-in knowledge and application of Active Semantic Model (ASM), neural networks, languages based on predicate logic, etc.

WP6. Design of Anatomically Shaped Lattice Scaffold

Leader: Asst. Prof. dr Milos Stojkovic

The special attention in research is devoted to development and optimization of design of Anatomically Shaped Lattice Scaffold. That is in-house developed new design concept of scaffold aimed to bone tissue recovery. The main objective of this work package is to develop method for easy and fast customization of lattice scaffold design to the anatomy of the traumatized bone tissue region of a particular patient. Moreover, this work package should define guidelines for a new product-service to the bio-medical market, which covers the whole process from redesigning of traumatized region of bone tissue up to fabrication of time biodegradable ASLS.